Can you Mix Tylenol and Advil?

Acetaminophen or Tylenol (OTC) can be used to ease pain.

These are two types of pain relievers. Acetaminophen is sometimes called APAP. Ibuprofen is a nonsteroidal, anti-inflammatory drug (NSAID).

Generally, it’s safe to take acetaminophen and ibuprofen together, but you’ll want to pay close attention to how much you take of each medication.

The key to safely taking acetaminophen and ibuprofen is knowing how much you’re taking at a time and how often.

Acetaminophen dosage

Over 12 years of age, the safest dose of acetaminophen should not exceed 4,000 mg (mg) per daily. But even this amount can harm some people’s livers, so aim for no more than 3,000 mg per day.

For children under the age of 12, it’s best to check with their healthcare provider to determine the safest dose for their body weight.

Be aware that OTC medications may contain acetaminophen, in various doses. Usually, 325 mg to 500 mg or 650 mg.

Some OTC brand-name medications may contain acetaminophen.

Keep in mind: Acetaminophen might be listed as APAP on labels.

Ibuprofen dosage

Limit your intake to 1,200mg of ibuprofen per day. OTC ibuprofen comes in 200mg pills. This means that you will need six pills per day. However, it is important to verify how many pills are in each one.

Again, for children, it’s best to ask their healthcare provider about the safest dose for their weight.

If you have prescription-strength ibuprofen, talk to your prescriber before mixing it with any other medications, including acetaminophen.


The following are the recommended limits of adults and children above 12 years old:

  • 3,050 mg of acetaminophen per day
  • 1,200 mg of ibuprofen daily

For children younger than 12, consult your healthcare provider.

You can take both ibuprofen AND acetaminophen together. You should not take more than the recommended dosage.

People may experience stomach or abdominal pain if they take the two medications together. In this case, it’s better to alternate when you take each medication.

You could, for example, take ibuprofen first and then acetaminophen 4 hours later. Then, repeat the process as necessary.

You can also alternate days. You could also alternate days. For instance, if you take ibuprofen Monday, then take acetaminophen Tuesday.

Acetaminophen may be safely mixed in with other NSAIDs like aspirin (Aleve) and naproxen. You should follow the same rules as if you were using acetaminophen with ibuprofen.

Ibuprofen, however, shouldn’t be mixed with other NSAIDs. Because all NSAIDs have the same mechanism to relieve pain, this is why you shouldn’t mix Ibuprofen with other NSAIDs. You could increase the effect of NSAIDs by increasing your dosage.

If you’ve already mixed acetaminophen and ibuprofen but are concerned that you’ve taken too much of either medication, there are a few symptoms you’ll want to watch for.

If you feel any of the following symptoms after taking acetaminophen and ibuprofen, please contact your healthcare provider immediately.

  • Tinnitus (ringing or ringing in the ears).
  • Heartburn
  • convulsions
  • nausea and vomiting
  • You should sweat
  • stomach pain
  • diarrhea
  • dizziness
  • Blurred vision
  • Rashes

Acetaminophen (OTC pain reliever) and ibuprofen (OTC pain reliever) are two examples. While it’s safe to take the two together, it’s important to make sure you aren’t taking more than the recommended amount of each.

Check the labels of any other OTC medications you’re taking to make sure they don’t already contain acetaminophen.

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