Side Effects, Dosage, Uses & More

Celecoxib oral capsule is offered as a generic drug and a brand-name drug. Model identify: Celebrex.

  1. Celecoxib solely comes as a capsule you’re taking by mouth.
  2. This drug is used to deal with numerous types of arthritis, short-term ache, and menstrual cramps.

Celecoxib oral capsule is a prescription drug that’s obtainable because the brand-name drug Celebrex. It’s additionally obtainable in a generic model. Generic medication normally price much less. In some circumstances, they is probably not obtainable in each power or type because the brand-name model.

Celecoxib solely comes as a capsule you’re taking by mouth.

Why it’s used

This drug is used to deal with:

  • rheumatoid arthritis
  • osteoarthritis
  • ankylosing spondylitis
  • short-term ache
  • menstrual cramps

The way it works

This drug belongs to a category of medication known as nonsteroidal anti-inflammatory medication (NSAIDs). A category of medication is a gaggle of medicines that work in an identical manner. These medication are sometimes used to deal with comparable circumstances.

NSAIDs block an enzyme known as cyclooxygenase (COX). COX works in your physique to provide chemical substances that trigger ache and irritation. By blocking COX, NSAIDs like this drug cease these chemical substances from forming. This, in flip, reduces ache and irritation.

Celecoxib oral capsule doesn’t trigger drowsiness, however it may possibly trigger different uncomfortable side effects.

Extra widespread uncomfortable side effects

The extra widespread uncomfortable side effects that may happen with celecoxib oral capsule embody:

  • abdomen ache
  • constipation
  • diarrhea
  • gasoline
  • heartburn
  • nausea
  • vomiting
  • dizziness
  • headache
  • respiratory tract an infection

If these results are gentle, they could go away inside a couple of days or a few weeks. In the event that they’re extra extreme or don’t go away, speak to your physician or pharmacist.

Critical uncomfortable side effects

Name your physician instantly in case you have severe uncomfortable side effects. Name 911 in case your signs really feel life-threatening or when you assume you’re having a medical emergency. Critical uncomfortable side effects and their signs can embody the next:

  • Chest ache or coronary heart assault
  • Stroke. Signs could embody:
    • sudden weak spot in a single half or aspect of your physique
    • slurred speech
    • drooping on one aspect of your face
    • blurred imaginative and prescient
    • sudden dizziness or bother strolling
    • very extreme headache with no different trigger
  • Hypertension
  • Edema. Signs could embody:
    • swelling in your legs and arms, fingers and ft
    • uncommon weight acquire
  • Bleeding and ulcers in your abdomen and gut. Signs could embody:
    • blood in urine
    • vomiting
    • bloody stools
    • black and sticky stools
  • Pores and skin reactions, together with rash or blisters
  • Allergic reactions. Signs could embody:
    • itching and hives
    • swelling of your face or throat
  • Liver issues. Signs could embody yellowing of your pores and skin or whites of your eyes.
  • Bronchial asthma assaults

Disclaimer: Our objective is to offer you probably the most related and present data. Nonetheless, as a result of medication have an effect on every individual in another way, we can’t assure that this data consists of all attainable uncomfortable side effects. This data will not be an alternative choice to medical recommendation. All the time focus on attainable uncomfortable side effects with a healthcare supplier who is aware of your medical historical past.

Celecoxib oral capsule could work together with different medicines, herbs, or nutritional vitamins you could be taking. That’s why your physician ought to handle your entire medicines fastidiously. In case you’re interested by how this drug may work together with one thing else you’re taking, speak to your physician or pharmacist.

Be aware: You may scale back your probabilities of drug interactions by having your entire prescriptions stuffed on the identical pharmacy. That manner, a pharmacist can verify for attainable drug interactions.

Examples of medication that may trigger interactions with celecoxib are listed beneath.

Blood thinner, anticoagulant

Combining warfarin and celecoxib raises your threat of bleeding.

Psychological well being drug

Celecoxib could improve the degrees of lithium in your physique. Indicators of lithium toxicity embody slurred speech and tremors.

Blood stress medication

Celecoxib could scale back the blood pressure-lowering results of sure blood stress medication. Examples of those medication embody:

  • antiotensin-converting enzyme (ACE) inhibitors
  • angiotensin II receptor blockers
  • diuretics

Transplant drug

Combining cyclosporine and celecoxib raises your threat of kidney injury.

Most cancers medication

Taking celecoxib with sure medication used to deal with most cancers raises the danger of uncomfortable side effects from these medication. These uncomfortable side effects embody kidney injury and a lower in cells that allow you to combat an infection. Examples of those medication embody:

Different NSAIDs

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). Combining it with different NSAIDs will increase your threat of uncomfortable side effects. Examples of different NSAIDs embody:

Corticosteroids

Combining celecoxib with corticosteroids equivalent to prednisone raises your threat of abdomen bleeding.

Digoxin

In case you take celecoxib with digoxin, the degrees of digoxin in your physique could also be elevated. In case you take these medication collectively, your physician could monitor your digoxin ranges.

Antidepressants

Combining celecoxib with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) will increase your threat of abdomen bleeding. Examples of SSRIs and SNRIs embody:

  • citalopram (Celexa)
  • paroxetine (Paxil)
  • sertraline (Zoloft)
  • venlafaxine (Effexor)
  • duloxetine (Cymbalta)

Disclaimer: Our objective is to offer you probably the most related and present data. Nonetheless, as a result of medication work together in another way in every individual, we can’t assure that this data consists of all attainable interactions. This data will not be an alternative choice to medical recommendation. All the time converse together with your healthcare supplier about attainable interactions with all prescribed drugs, nutritional vitamins, herbs and dietary supplements, and over-the-counter medication that you’re taking.

This drug comes with a number of warnings.

Hypertension warning

This drug could trigger you to develop hypertension or could worsen hypertension. Take this medicine with warning in case you have hypertension. Verify your blood stress earlier than and whereas taking this drug.

Bronchial asthma warning

Take this drug with warning in case you have bronchial asthma. It might trigger narrowing in your airways, which might result in dying. In case your bronchial asthma worsens whilst you take this drug, get instant medical consideration.

Allergy warning

This drug could cause a extreme allergic response. Signs could embody:

  • bother respiration
  • swelling of your throat or tongue
  • hives

When you have an allergic response, name your physician or native poison management heart instantly. In case your signs are extreme, name 911 or go to the closest emergency room. Don’t take this drug once more when you’ve ever had an allergic response to it. Taking it once more might be deadly (trigger dying).

Alcohol interplay warning

Combining alcohol with celecoxib raises your threat of abdomen bleeding.

Smoking warning

Smoking whereas taking celecoxib raises your threat of abdomen bleeding.

Warnings for individuals with sure well being circumstances

For individuals with coronary heart illness: When you have a historical past of coronary heart illness or are in danger for coronary heart illness, you shouldn’t take celecoxib. It raises your threat of blood clots, coronary heart assault, and stroke.

For individuals with abdomen issues: When you have a historical past of abdomen bleeding or ulcers, you’re at larger threat of getting one other ulcer or bleeding occasion, which can be deadly.

For individuals with sulfonamide “sulfa” allergy: In case you’re allergic to medicines that comprise sulfonamide, you shouldn’t take this drug. This drug accommodates sulfonamide. You could have severe pores and skin reactions. Report any pores and skin rash to your physician instantly.

Warnings for different teams

For pregnant girls: This drug falls into one in every of two being pregnant classes, relying on how far alongside you might be in your being pregnant. In your first 30 weeks of being pregnant, it’s a class C being pregnant drug. This class means two issues:

  1. Analysis in animals has proven hostile results to the fetus when the mom takes the drug.
  2. There haven’t been sufficient research finished in people to make sure how the drug may have an effect on the fetus.

After 30 weeks of being pregnant, this drug is a class D being pregnant drug. For this class:

  1. Research present a threat of hostile results to the fetus when the mom takes the drug.
  2. The advantages of taking the drug throughout being pregnant could outweigh the potential dangers in sure circumstances.

Inform your physician when you’re pregnant or plan to turn into pregnant. This drug needs to be used throughout being pregnant provided that the potential profit justifies the potential threat to the fetus.

Name your physician instantly when you turn into pregnant whereas taking this drug.

For ladies who’re breastfeeding: This drug has been proven to move by means of breast milk. You and your physician ought to resolve when you’ll take this drug or breastfeed.

For seniors: This drug has been studied in a small variety of individuals older than 65 years. In case you’re 65 years or older, you will have elevated threat of abdomen issues and kidney failure which may be deadly.

For youngsters: This drug hasn’t been studied in individuals youthful than 2 years.

This dosage data is for celecoxib oral capsule. All attainable dosages and types is probably not included right here. Your dose, type, and the way typically you’re taking it is going to rely on:

  • your age
  • the situation being handled
  • how extreme your situation is
  • different medical circumstances you may have
  • the way you react to the primary dose

Types and strengths

Generic: Celecoxib

  • Type: oral capsule
  • Strengths: 50 mg, 100 mg, 200 mg, and 400 mg

Model: Celebrex

  • Type: oral capsule
  • Strengths: 50 mg, 100 mg, 200 mg, and 400 mg

Dosage for osteoarthritis

Grownup dosage (ages 18 years and older)

The standard dosage is 200 mg taken as soon as per day, or 100 mg taken twice per day in evenly spaced doses.

Youngster dosage (ages 0 to 17 years)

A secure and efficient dosage hasn’t been established for this age group.

Dosage for rheumatoid arthritis

Grownup dosage (ages 18 years and older)

The standard dosage is 100–200 mg taken twice per day in evenly spaced doses.

Youngster dosage (ages 2 to 17 years), for juvenile rheumatoid arthritis

  • For youngsters who weigh 22–55 kilos (10–25 kg), the standard dosage is 50 mg taken twice per day in evenly spaced doses.
  • For youngsters who weigh greater than 55 kilos (25 kg), the standard dosage is 100 mg taken twice per day in evenly spaced doses.

Youngster dosage (ages 0 to 1 years)

Dosage hasn’t been established for youngsters youthful than 2 years.

Dosage for ankylosing spondylitis

Grownup dosage (ages 18 years and older)

  • The standard dosage is 200 mg taken as soon as per day or 100 mg taken twice per day in evenly spaced doses.
  • If celecoxib isn’t working after 6 weeks, your physician could strive 400 mg per day (single or divided doses).

Youngster dosage (ages 0 to 17 years)

A secure and efficient dosage hasn’t been established for this age group.

Dosage for short-term ache

Grownup dosage (ages 18 years and older)

  • The standard dosage is 400 mg for the primary dose, adopted by a 200-mg dose about 8–12 hours later if wanted.
  • On following days, the standard dosage is 200 mg taken twice per day as wanted.

Youngster dosage (ages 0 to 17 years)

A secure and efficient dosage hasn’t been established for this age group.

Dosage for menstrual cramps

Grownup dosage (ages 18 years and older)

  • The standard dosage is 400 mg for the primary dose adopted by a 200-mg dose about 8–12 hours later if wanted.
  • On following days, the standard dosage is 200 mg taken twice per day as wanted.

Youngster dosage (ages 0 to 17 years)

A secure and efficient dosage hasn’t been established for this age group.

Particular concerns

Individuals with liver illness: Having liver illness could scale back your means to clear this drug out of your physique, which might result in extra uncomfortable side effects. When you have average liver illness, your each day dose of celecoxib could also be diminished by half. When you have extreme liver illness, you shouldn’t take this medicine.

Disclaimer: Our objective is to offer you probably the most related and present data. Nonetheless, as a result of medication have an effect on every individual in another way, we can’t assure that this record consists of all attainable dosages. This data will not be an alternative choice to medical recommendation. All the time converse together with your physician or pharmacist about dosages which are best for you.

Celecoxib oral capsule could also be used for short-term or long-term therapy, relying in your situation. This drug has dangers when you don’t take as prescribed by your physician.

In case you cease or miss doses: In case you cease taking this drug, miss doses, or don’t take it on schedule, you could expertise extra ache brought on by your situation.

In case you take an excessive amount of: Taking an excessive amount of will increase your threat of experiencing uncomfortable side effects.

What to do when you miss a dose: In case you miss your dose, take it as quickly as you may. Nonetheless, if it’s just some hours till your subsequent dose, skip the missed dose. By no means attempt to catch up by taking two doses without delay. This might end in poisonous uncomfortable side effects.

Easy methods to inform if the drug is working: You could possibly inform this drug is working when you expertise much less ache.

Maintain these concerns in thoughts in case your physician prescribes celecoxib oral capsule for you.

Normal

  • Whether or not you need to take this drug with meals relies on your dosage. In case you take 400 mg of celecoxib twice per day, you need to take it with meals for higher drug absorption. In case you take as much as 200 mg celecoxib twice per day, you may take it with or with out meals.
  • You may open the capsule if you could.
  • When you have bother swallowing the capsule, you may open it and sprinkle the contents onto a degree teaspoon of cool or room-temperature applesauce. Eat the applesauce instantly together with some water.

Storage

  • Retailer at room temperature between 68°F and 77°F (20°C and 25°C). Sometimes, you may retailer it at temperatures between 59°F and 86°F (15°C and 30°C).
  • Maintain this drug away from mild.
  • Don’t retailer this medicine in moist or damp areas, equivalent to loos.

Refills

A prescription for this medicine will not be refillable. You or your pharmacy must contact your physician for a brand new prescription when you want this medicine refilled.

Journey

When touring together with your medicine:

  • All the time carry your medicine with you. When flying, by no means put it right into a checked bag. Maintain it in your carry-on bag.
  • Don’t fear about airport X-ray machines. They will’t harm your medicine.
  • Chances are you’ll want to point out airport workers the pharmacy label on your medicine. All the time carry the unique prescription-labeled field with you.
  • Don’t put this medicine in your automobile’s glove compartment or go away it within the automobile. Remember to keep away from doing this when the climate could be very sizzling or very chilly.

Medical monitoring

Your physician will verify your blood stress earlier than and through therapy with celecoxib. Your physician may do blood assessments to verify how properly your liver and kidneys are functioning throughout therapy.

Solar sensitivity

Chances are you’ll be extra delicate to daylight when you take celecoxib. Shield your self from the solar:

  • Put on sun-protective clothes.
  • Use sunscreen—SPF 15 or larger.
  • Restrict your time in direct daylight.
  • Keep away from tanning beds.

Insurance coverage

Many insurance coverage firms require a previous authorization for this drug. This implies your physician might want to get approval out of your insurance coverage firm earlier than your insurance coverage firm pays for the prescription.

There are different medication obtainable to deal with your situation. Some could also be extra appropriate for you than others. Discuss to your physician about attainable alternate options.

Disclaimer: Healthline has made each effort to make sure that each one data is factually appropriate, complete, and up-to-date. Nonetheless, this text shouldn’t be used as an alternative choice to the data and experience of a licensed healthcare skilled. It is best to at all times seek the advice of your physician or different healthcare skilled earlier than taking any medicine. The drug data contained herein is topic to alter and isn’t supposed to cowl all attainable makes use of, instructions, precautions, warnings, drug interactions, allergic reactions, or hostile results. The absence of warnings or different data for a given drug doesn’t point out that the drug or drug mixture is secure, efficient, or acceptable for all sufferers or all particular makes use of.

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